The outbreak of the COVID-19 epidemic has great impact on human society. It not only changes the performance of global economy，but also challenges the operation and management of enterprises，causing the adjustment of human resources management in enterprises. In the epidemic era，flexible working methods such as home office and online recruitment are prevalent，while traditional modes of human resource management can’t adapt to the rapid changes of the environment well. Flexible-oriented human resource management system is a necessary choice for enterprises to effectively cope with the future uncertainty and the complexity of market competition. This paper analyzes the evolution and research status of flexible-oriented human resource management，explores its development in the epidemic era，analyzes the existing problems，and puts forward research prospects and suggestions.