In 2021，the scale of Chinese digital economy reached 45.5 trillion-yuan，nominal growth rate reached 16.2%，and accounted for 39.8% of GDP. In the past year，the digital economy in the Yangtze River Economic Belt region has also developed significantly. From the perspective of digital industrialization，the electronic information manufacturing industry in the Yangtze River Economic Belt accounted for about 1/2 of the national proportion，and the growth rate of the software and information technology service industries was more than 10%. From the perspective of industrial digitization，the scale of industrial digitization in Jiangsu，Zhejiang，Shanghai，Hubei，Sichuan，Hunan，Anhui，Chongqing，and Jiangxi all exceeded 1 trillion yuan. In addition，e-commerce，big data and artificial intelligence in the Yangtze River Economic Belt performed well in 2021. Looking forward to 2022，the digital economy in the Yangtze River Economic Belt will become an important driving force for economic development in the post-epidemic era. The network infrastructure will be further improved，the pace of digital transformation will be accelerated，and the digital economy will develop better in coordination.