Through the construction of the science and technology（S&T） innovation driving force index evaluation system for the cities in Yangtze River Delta，and based on the AHP-EVM model to set the weight of the subjective-objective comprehensive indicators，this paper gets the S&T innovation driving force composite index，including four special indices of the S&T innovation input，the S&T innovation carrier，the S&T innovation output，the S&T innovation performance，as well as 10 secondary indicators score.The driving forces of science and technology innovation of 41 cities in the Yangtze River Delta are evaluated comprehensively and systematically，and the driving forces of science and technology innovation of urban agglomerations in the Yangtze River Delta are analyzed by stratification，and the impact of COVID-19 was examined by comparing with 2019.