Because of the negative macro shocks including Sino-US trade war and COVID-19 and etc.，the Index for Mass Innovation and Entrepreneurship（IMIE）of 2021 kept declining. The change of IMIE differs from previous year. First，the IMIE of cities with high initial scores declined significantly. Second，the most important reason for the IMIE decline is the decline of the environment support score，and then is the value efficiency score，and finally the resource capacity score. By the stratification of cities，the negative macro shocks enlarge the within-group heterogeneity. The response patterns of negative macro shocks provide hints for future optimization of the policy design.