In 2021，Major changes have taken place in the regional diplomatic agenda，Vaccine diplomacy in the form of cooperation and assistance has become the focus of Latin American countries’ foreign exchanges. The major changes in the diplomatic agenda of the U.S.government have a direct impact on the turning of the diplomatic agenda of Latin American countries. Regional cooperation is moving forward with difficulty. The CELAC plays a leading role in the regional integration，the problems of the Mercosur continue to grow because of disputes between its various member-states，and the Pacific Alliance is looking for friends in the Asia Pacific region. In 2022，we need to pay attention to the development of U.S.-Latin America relations，and the tendency of Latin America’s Strategic Autonomy.