With the spread of COVID-19 worldwide，the epidemic situation in Southeast Asia has experienced several twists and turns，and the epidemic prevention and control policies of various countries have been adjusted accordingly. In this context，the political and economic situation in Southeast Asian countries has experienced a series of structural changes. With the exception of the return of the Myanmar military to politics，the political situation in all countries remains relatively stable，even though it is also deeply affected by the election cycle and political structure. In 2021，the economic growth rate of Southeast Asian countries generally turned to positive，showing a recovery growth situation. Looking ahead to 2022，the epidemic situation in Southeast Asia is still unpredictable. Due to the continued emergence of the new strain of COVID-19，the duration and future trend of the epidemic is full of uncertainties. In the first half of the year，the general elections in Timor-Leste and the Philippines have been concluded. In the second half of the year，Malaysia and Thailand will hold general elections. With the global economic recovery and the expansion of international market demand，the economy of Southeast Asian countries will continue to recover，but the rise of international commodity prices and the tightening of monetary policies in Europe and the United States will lead to inflation and financial market fluctuations in Southeast Asian countries.