the Yangtze River Delta region is the most developed economic zone with the most active innovation and the highest degree of urbanization in our country. It has formed advantage industries such as integrated circuit，high-end equipment manufacturing，new energy vehicles and artificial intelligence. In the face of the contraction of overseas supply chain and global market demand brought by COVID-19，Europe and the United States are blocking China in cutting-edge technology and high-end industries against the background of global trade war，and preventing the overall upgrading of China’s industrial chain. How to give play to the early advantages of the Yangtze River Delta，create a more innovative，safer and reliable industrial chain，and achieve the overall upgrading of the industrial chain is an important issue for the Yangtze River Delta region to focus on in the future.