Science and technology is always the first productive force，and science and technology innovation is the strategic support to improve social productivity and comprehensive national power. In recent years，the ZTE、Meng Wanzhou and the other related events happened，which all indicate the importance of core science and technology. “Backward will be beaten” is still exists in the 21st century，especially in the field of science and technology. At present，although China’s independent innovation capability is increasing day by day，but it should be noted that the overall innovation effectiveness of China is not high，and the innovation power of enterprises is insufficient，so it is not realistic to rely solely on the government to support the development of national science and innovation. The PPP model provides a new path to promote China’s innovation-driven development，and has becoming an important means to develop science and technology in China. In the article，by studying the national science and technology PPP projects with special focus on three cases of science and technology PPP projects，we analyze the experiences and practices，summarize the highlights，and finally put forward the problems and suggestions in the PPP model to promote science and technology innovation strategy.