Under the background of the normalization of the COVID-19 epidemic Prevention and Control，new media has become the main channel for the public to obtain information. It has become the top priority of current work to widely spread the esoteric and obscure health science knowledge through various forms of new media channels，so that the public can understand and master the knowledge of epidemic prevention. This article will combine the cases on new media platforms such as WeChat，Weibo，Douyin，and Station B to discuss the new changes and new requirements for popular science communication in the context of epidemic prevention and control，sort out the characteristics and problems of new media popular science communication，and propose new media popular science popularization. Spread the value orientation in the new situation.