The year 2021 witnessed the successive changes of both governments in Iran and the U.S. After taking power，the Raisi administration implemented a new strategy called “Nullifying U.S sanctions” to deal with the issue. Iran adjusted the status of Vienna Negotiation in its foreign policies，strengthening its nuclear ability greatly，reducing its cooperation level with IAEA，actively engaging so called “Peripheral Diplomacy” and “Economic Diplomacy” to impair the Impact of U.S. sanctions and meet the challenges in regional competition，as well as to get fully prepared for the restart of Vienna Negotiation. In addition to the long-standing interference factors like domestic politics in both Iran and the U.S. and geopolitical games，the Ukraine Crisis is a new complicated variable. The year 2022 is decisive for the negotiation. There are two prospects for reviving the deal，a new agreement may be dealt or else the negotiation may be broken.