The general characteristics of international relations in the Middle East from 2021 to 2022 appear：the policies of major powers are further adjusted，the relations between regional countries are significantly eased，and the Middle East countries actively carry out independent and active diplomacy to meet the challenges of external factors. After Biden became the president of U.S.，he corrected the deviation of his predecessor Trump’s Middle East policy，but the actual effect was limited. The Middle East Strategy of the U.S. is still in the process of strategic contraction. The Iranian nuclear issue has become the focus of U.S.’ Middle East policy，but the Biden administration wavered in its determination to sign a new Iranian nuclear agreement. On the issue of peace in the Middle East，U.S. supports Israel and some Arab countries to improve relations but does nothing to promote negotiations between Israel and Palestine. For a time，Russia lacked strong diplomatic stamina in the Middle East. It showed some performance on the Syrian issue and the Iranian nuclear issue，but the results were limited. Instead，it focused on improving bilateral relations with Turkey，Iran，Israel and other countries. Among the EU countries，the German has changed the presidency，and Macron has been reelected as French president. Both German and French lack the motivation to cooperate on the Middle East issue，which makes the EU more willing than able on the hot issues in the Middle East. Relations between countries in the Middle East have been further eased，relations between Israel and Turkey have improved significantly，relations with Gulf Arab countries such as the United Arab Emirates have further heated up，and relations between Saudi Arabia and Iran has also slowed down，indicating that the endogenous factors of the changes in international relations in the Middle East have increased significantly.