Since 2021，the turbulent ME region has shown a positive trend of détente：the three major regional conflicts in Syria，Libya and Yemen have cooled down；Turkey took the initiative to ease tensions with regional countries；Reconciliation among GCC countries；Iran began to talk with Saudi Arabia；Negotiations for the U.S. to rejoin the JCPOA began. The trend of regional détente is driven by a variety of internal and external factors，and its sustainability remains uncertain. In response to the regional security vacuum created by the accelerated withdrawal of the United States，countries in the region are speeding up the restructuring of alliances，and several small multilateral security mechanisms have emerged. The Ukraine Crisis has spilled over into the Middle East，exposing countries in the region to multiple security crises，including the epidemic，food，energy，financial and bloody conflicts. This has seriously jeopardized the political，economic and social stability of countries in the region，and brought new uncertainties to the resolution of regional crises，including the Iranian nuclear issue and the Syrian war.