While the U.S. declares its intent to simultaneously “cooperate，compete and confront” China，great power competition，security alliance and objective “decoupling” remain as the main theme of U.S.’ China policy. As the core element of U.S. global strategy，the security-based cooperation in the “Indo-Pacific” region deepens in 2022，undisturbed by the Ukrainian crisis and a series of global issues. The Biden administration continues to promote U.S.-led cooperative frameworks in “Indo-Pacific”，launching multiple campaigns persuading countries in the region to “stay close” with the U.S. and “stay away” from China. Furthermore，the Biden Administration intends to facilitate the cooperation between U.S. allies in Asia and Europe，especially by enhancing the cooperation of Asia-Pacific countries and NATO. The U.S.，as well as its allies，also takes more aggressive stances in the “core interests” of China，especially the cross-strait relationship. While claiming China as the “aggressor” who changes status quo，the U.S. is actually undermining the regional stability and cooperation in Asia-Pacific via its security-based and ideology-driven strategy.