2021 is the first year of the implementation of the 14th Five-Year Plan. Guizhou Province thoroughly implements the spirit of the 19th National Congress of the Communist Party of China（CPC）and all previous plenary sessions of the 19th CPC National Congress and spirit of Chinese President Xi Jinping’s important instructions for Guizhou work. In order to seize the new opportunities of digital economy strategy，Guizhou have deeply implemented the strategic action of big data. And then，taking the deep integration of big data and the real economy as the key to promote the construction of “four modernizations” of new industrialization，new urbanization，agricultural modernization and tourism industrialization continuously. Based on the evaluation data of the deep integration of big data and real economy in Guizhou Province in 2021，this paper deeply excavates and comprehensively analyzes the overall level of the integration and the value effect in enabling the “four modernizations”. And then，some countermeasures and suggestions，for example，consolidate the foundation of integrated development，continuously monitor the current situation of integrated development and implement policies for the classification of characteristic industries are put forward to promote the deep integration of big data and real economy，so as to enable the construction of “four modernizations” in Guizhou Province.