With the rapid development of cutting-edge biotechnology，Advanced Therapy Medicinal Products （ATMPs），represented by cellular and gene therapy drugs，continue to emerge. Such technologies and products bring hope to the treatment of diseases and human dysfunctions that cannot be treated by current medicine. Due to the complexity，heterogeneity，interaction with the environment，and easy degradability of the active ingredients of ATMPs，the selection of excipients/packaging materials has brought great challenges to developers. These challenges are closely related to the quality，safety and effectiveness of ATMPs. This paper discusses the stability of ATMP cell raw materials and the production characteristics of ATMPs，and reviews the use of excipients/packaging materials in ATMPs currently sold in the United States，Europe and Japan，and finally proposes some questions and suggestions on the current development of ATMP excipients/packaging materials.