In 2020，the biopharmaceutical industry has bucked the trend against the breakout of COVID-19 epidemic，creating a new speed in the R&D of innovative biopharmaceuticals. This paper points out that the accelerated approval of a series of innovative COVID-19 vaccines has contributed to the fight against the epidemic. This paper describes the layout of multinational pharmaceutical companies in mRNA，and introduces the current international and domestic research and development progress in bispecific antibodies，antibody-conjugated drugs，CAR-T therapy which are the focus of biopharmaceuticals.