This paper discusses that under the dual pressure from increasingly strengthened domestic government supervision and increasingly severe international trade environment，the compliance management of pharmaceutical companies is facing more stringent requirements. Strengthening compliance management has become compulsory for every pharmaceutical company. Compliance management of pharmaceutical companies is the foundation and key to national and industry credit supervision. In the face of increasingly exposed compliance failures of pharmaceutical companies，speeding up the construction of a compliance management system has become a key issue for pharmaceutical companies to urgently solve. Pharmaceutical industry associations actively lead enterprises to draft the “Pharmaceutical Industry Compliance Management Regulations” to enhance corporate risk prevention and control capabilities and improve credit levels，ensure compliance and efficient operation of companies，and at the same time assist national regulatory authorities to explore and implement administrative reconciliation with compliance and no-suit with compliance in the pharmaceutical industry.