Improving the management level of EHS （Environment，Occupational Health and Safety） is a requirement for the transformation，upgrading and sustainable development of China’s pharmaceutical industry. How to perform well in the EHS management in the R&D of new drugs is a new topic faced by many companies. Two aspects should be considered in the EHS management in the R&D of new drugs：various research and development activities should meet the requirements of environmental protection，safety management，and occupational health management；with the concept of EHS by Design，to reduce the generation of waste water，waste gas and residue from the start of product development，and solve intrinsic safety problems from the source of the process. In terms of environmental protection，companies should establish the concept of clean production and promote the application of green chemical technologies. In terms of safety management，companies should pay attention to the collection and maintenance of process safety information，conduct process hazard analysis，and ensure the safe operation of laboratories. In terms of occupational health，companies should identify existing occupational disease hazards，establish a hazard assessing and monitoring system，and adopt appropriate control measures to reduce occupational health risks of employees.