At present，China’s economic development has shifted from the high-speed growth stage to the high-quality development stage. To achieve high-quality economic development，the construction of modern industrial system should be put at the core. As the center of Guangdong-Hong Kong-Macao Greater Bay Area and the capital city of China’s strongest economic province，Guangzhou has initially formed a modern industrial system in which advanced manufacturing，modern services and strategic emerging industries are mutually reinforcing，but it still faces problems such as unbalanced industrial structure，single growth driver，unreasonable spatial layout and insufficient supporting factors. Under the background of the dual circulation，Guangzhou should form the industrial spatial layout of “one core，two wings，three belts and multiple poles”，cultivate new pillar industries，coordinate the three major momentums of system，technology and culture，focus on new consumption and urban consumer goods industry，upgrade the industrial chain and supply chain，intensify regional opening，and build a modern industrial system with reasonable layout，optimized structure，sustained power，balanced supply and demand，security，stability，openness and coordination.