Since the State Council approved the construction of Zhengzhou as a national central city，the city’s economic development has been generally stable with ever-improving innovation driver，industrial development momentum and ecological environment. The advantages of hub economy have been obvious，the reform and opening-up has been deepened，and the construction of the national central cities has reaped fruitful results. Faced with the interwoven effects of the triple pressures，the COVID-19 pandemic and extreme weather，there are still some urgent problems for Zhengzhou to solve in the process of building a national central city，such as the overall strength to be improved，the weak foundation of sci-tech innovation，and inadequate globalization and high-end elements support. In the future，Zhengzhou should coordinate epidemic prevention and socio-economic development，establish an innovation-driven national central city by implementing strategies based on innovation，science，education and talents，and carry out target-oriented，question-oriented and consequence-oriented activities to make Zhengzhou innovative，strong，resilient and a hub city with sophisticated industrial system，and make greater contributions to the province and even the whole country.