Shenzhen implemented all important guidance ideology of General Secretary Xi Jinping on deepening the reform of the medical and healthcare system thoroughly in 2021，coordinating epidemic prevention and control with the quality development of health system，enhancing the whole health system to a new stage of quality development by accelerating the construction of Public Health Service System，improving the integrated Quality and Efficient Medical Service System，furthering the Reform and Quality Qevelopment of Public Hospital，and accelerating the Construction of Healthy Shenzhen. The containment of the mutant strain of COVID-19 has achieved absolute victory periodically in Shenzhen，no nosocomial infections among medical staff and hospital outbreaks accured；Building Quality and Efficient Medical and Health Service System was selected as one of the 47 experience cases of national promoting innovation approaches of Shenzhen demonstration pilot zone；The construction of modern hospital management system was affirmed by the National Development and Reform Commission of the People’s Republic of China，and the relevant experience was published in the Reform Brief of the National Development and Reform Commission of the People’s Republic of China and the Journal of Study and Research sponsored by the Policy Research Office of the CPC Central Committee. The University of Hong Kong-Shenzhen Hospital has been awarded as Quality Development Pilot Hospital of Provincial Committe and National Pilot Hospital of Modern Hospital Management System. Shenzhen Municiple Health Commision will devote a great deal of energy promoting the further improvement of the population healthy comprehensively in 2022，such as ensuring the regular epidemic prevention and control with strict and solid measures and accelerating the expansion of superior medical resources by focusing on people’s livelihood，insisting to Green Medical Culture and accelerating the Reform and Quality Qevelopment of Public Hospital，focusing on the weak links and accelerating the Construction of Healthy Shenzhen，strengthening the innovation-driven and accelerating the demonstration and leadership of health care reform in China，Optimizing support and security and accelerating to establish innovative highland of talent，information，scientific technology.