The global outbreak and spread of COVID-19 has severely impacted world economic and trade activities，and China-Latin America economic and trade relations are also facing the huge challenge of COVID-19 after more than a decade of rapid development. The three major engines including trade，investment and financial cooperation between China and Latin America and the Caribbean have been hit by COVID-19 in the short term. However，trade in medical supplies，investment in health infrastructure and the Digital Silk Road have become new driving forces for China-Latin America economic and trade cooperation under the impact of COVID-19. Looking ahead，although the development of China-Latin America economic and trade cooperation in the field of trade，investment and international engineering contracting is hampered by COVID-19，the overall long-term positive trend remains unchanged and the vision of bilateral cooperation has become stronger under the influence of COVID-19. China and Latin America should continue to take the Belt and Road Initiative as a guide，explore new opportunities for China-Latin America economic and trade cooperation under the digital economy and China’s dual circulation development pattern，and promote the broad scope and deep level development of China-Latin America economic and trade cooperation to achieve optimization and upgrading.