The culture regional differences of the city with ancient culture are the most prominent characteristics. The diversity differences，aggregation and hierarchy are also very obvious，and the differences are caused by the development of industrialization，the baptism of market economy and the influence of digital technology. Driven by digital technology，some cities with ancient culture have made full use of the advantages of digital technology to form an industrial ecological chain from cultural and tourism resources to cultural and tourism elements，and then to the integration of physical industries. However，there are still some problems in some cities with ancient culture，such as insufficient support for culture applications by science and technology，lagging development of emerging cultural industries and emerging formats，difficulty in establishing modern business concepts，and insufficient preparation for organizational change facing digital transformation. Therefore，the industrial ecological construction of digital driven ancient cities needs to adhere to deepening reform，optimizing the development environment. Based on the construction of new infrastructure capacity and the digital transformation and innovation of traditional culture，the core technology ecology and characteristic cultural industry will be built with keeping the initiative in our own hands. Adopt the echelon industrial development strategy，take the cities with ancient culture as the objects to carry out hierarchical layout，distinguish the scale and level，and then organize the construction. Take demand as the traction，and use digital technology to realize the industrialized transformation of cultural creativity and the immersive remodeling of cultural consumption. Adopt the way of building vision，overall design and small step entry，and realize the orderly development of the construction through market acceleration. Pay attention to the influence of the digital twin production mode of meta cosmic culture and the service mode of cultural supply.