In 2021，the economic development of the central region was stable and improving，becoming one of the fastest growing regions in the country，and the tax revenue of the six central provinces increased significantly. In the first three quarters of 2021，the total economic output and total tax revenue of the six central provinces accounted for 21.99% of the country’s GDP and 21.79% of the total tax revenue in the same period，both hitting new highs in recent years. Through the analysis of the correlation between economy and taxation in the central region，it shows that the coordination between taxation and economic growth was obviously enhanced，and the taxation structure tended to be optimized. However，there are also problems such as the overall low macro tax burden，the uneven distribution of overall tax sources，and the lack of inter-provincial fiscal and tax cooperation mechanisms. In 2022，the basic judgment of the economic and taxation development in the central region is “stable and rising”，but it is also faced with the intensified adjustment of the global geopolitical and economic pattern，the further increase in the hidden worries of “quasi-stagflation” of the Chinese economy，and the fact that the combined force of economic development in the central region has not yet been fully formed，the central region’s tax revenue pressure will further increase and other risks and hidden worries. Looking forward to 2022 and the “14th Five-year Plan” period，it is suggested that the central region should build an inter-provincial fiscal and taxation cooperation mechanism under the guidance of the Central Committee of the Communist Party of China and the State Council’s “Opinions on Promoting High-quality Development of the Central Region in the New Era”，and give full play to the tax policy to guide industrial upgrading. We will optimize the tax support for “going out” enterprises，give full play to the role of tax regulation and distribution，enhance the momentum of high-quality tax services，further stimulate the vitality of market players，and promote the central region’s economy to move towards higher-level and higher-quality development.