The integration of the Yangtze River Delta is a major national development strategy，and the establishment of a tax collection，management and cooperation mechanism adapted to the development of the integration of the Yangtze River Delta is an important part of the overall framework of regional integration. In 2020，in the face of the repetition and impact of COVID-19 epidemic situation，the economy of the Yangtze River Delta took the lead in recovering，showing strong development resilience. Regional economic development has made steady progress，the total amount of tax revenue has decreased slightly，but the contribution to national tax revenue has increased slightly，and the macro tax burden rate has continued to decline since 2018. Under the measures of reducing taxes and fees and resuming work and production at the same time，the tax departments have made outstanding achievements in promoting “six stability” and “six guarantees”. In 2021，the cooperation mechanism of tax collection and management has been further improved，the regional economy of the Yangtze River Delta has become more active，and the optimization of the regional business environment has further stimulated the incremental effect of social asset investment. The proportion of GDP in the country is rising，and the tax increase is faster than that of the whole country. Looking forward to 2022，the opportunities and challenges of economic taxation in the Yangtze River Delta coexist. Only by firmly grasping the historical opportunity of integration，improving the cooperation mechanism of tax collection and management，continuously optimizing the regional business environment，promoting the integration of regional fiscal and taxation mechanisms，and building a win-win mechanism of tax collection and management coordination and benefit sharing，can we optimize the industrial structure，promote the Yangtze River Delta region to overcome various challenges，and move forward to a higher level of economic development.