Promoting the cross-border flow of labor and talents is an objective need to adapt to China’s economic and social development. With the deepening of the construction of the Guangdong-Hong Kong-Macao Greater Bay Area and the deepening of reform and opening up，the exchange and cooperation of young talents between the nine cities in the Pearl River Delta and Hong Kong and Macao has achieved rapid development. At present，the promotion of cross-border labor service cooperation in the Guangdong-Hong Kong-Macao Greater Bay Area has favorable conditions such as cultural and geographical advantages，complementary advantages of labor force，and promotion of regional economic integration. Problems and obstacles include inadequate policy formulation and publicity，poor flow of innovation elements，insufficient number of high-level talent development platforms，and imperfect inter-city talent collaboration mechanisms. In order to effectively attract young talents from Hong Kong and Macau in the Greater Bay Area to Guangzhou，a multi-level mechanism for the introduction of young talents from Hong Kong and Macau should be established and improved. The measurements include continuously promoting the construction of a high-level talent development platform，enhance the city’s international influence and talent’s basic public service guarantee capabilities，providing superior development space and living space；exploring the inter-city government affairs and talent coordination mechanism to maximize the effectiveness of talents and common development of the Greater Bay Area.