Small and medium-sized listed companies in the Yangtze River Delta are an important part of Listed Companies in the Yangtze River Delta and the country. In terms of scale，its number accounts for 80% of Listed Companies in the Yangtze River Delta，private enterprises account for more than 70% in terms of equity structure，manufacturing industry accounts for more than 70% in terms of industry structure，and net profit is higher than the national average in terms of profitability. At the same time，small and medium-sized listed companies in the Yangtze River Delta also have problems such as weak overall competitiveness，lack of professional collaborative division of labor，and weak basic R & D support capacity. In view of these problems，it is suggested that the government optimize the enterprise development environment，improve the industrial chain，promote enterprises to improve their innovation ability，and promote the high-quality development of small and medium-sized listed companies in the Yangtze River Delta.