The global COVID-19 prevention and control situation will remain grim and complex in 2021. Compared with 2020，the number and severity of travel-related food poisoning incidents decreased significantly in 2021. The incidence of travel-related infectious diseases was more frequent，and the level increased. The frequency and number of other travel-related public health incidents have decreased significantly，and the management of travel-related public health safety is still facing great challenges. Looking ahead to 2022，travel-related public health management will become smarter，with appointments and travel restrictions becoming the norm in the face of COVID-19. Travel-related public health management will be more precise，and short-range local travel and suburban travel will be obvious. International public health cooperation will be deepened，and the global travel market will gradually recover.