In 2021，due to the continuous transmission of novel coronavirus cases and the continuous variation of the coronavirus，the tourism industry has suffered a severe impact. The global COVID-19 prevention and control situation is still grim and complex，and the outbreak of COVID-19 caused by imported COVID-19 in China is on the rise. The overall situation of travel-related public health security is very severe，and travel-related public health incidents keep emerging. Compared with 2020，the number and severity of travel-related food poisoning incidents in 2021 were significantly lower. The incidence of infectious diseases is unusually frequent and the level is more serious. The frequency and number of other travel-related public health incidents have increased significantly，and the travel-related public health situation is facing severe challenges，especially the spread of COVID-19，which has profoundly changed the way people travel. The travel-related public health security situation in 2021 mainly includes：the intermittent spread of COVID-19 throughout the year，making it difficult to prevent public health security in tourism；the tourism industry carries out self-rescue of production recovery led by surrounding tourism，and many kinds of tourism public health accidents are hard to prevent. The global epidemic situation is complex and volatile，posing challenges to international cooperation on tourism public health. Development trend of travel-related public health in 2022：Tourism public health management has become smart and normal，and booking and travel restrictions have become normal in the face of COVID-19. The public health management of tourism is accurate and humanized，and the characteristics of short-range local tourism and suburban tourism are obvious. International public health coordination is becoming more professional，and the global travel market is gradually recovering.