With the wisdom of the construction of the hospital，various kinds of software emerge in endlessly，specialized subject of hospital business process optimization，system construction，information construction and application of medical quality management are also gradually deepened，good application of information system can improve work efficiency，comprehensively promote clinical raise health care’s quality and safety and quality management. The three cases provided in this report introduce the application of information system from the perspectives of emergency business process optimization，rehabilitation digital specialty construction，intelligent MDT security management of adverse events in hospitals，and improve the effectiveness of medical management.