This chapter discusses science popularization policy，science popularization infrastructure and how to use mass media and new media to popularize science in the UK，the United States and Japan. The development history of the three themes in three countries are illustrated，as well as focusing on their latest trends. This paper also selects typical and referential practical cases for reference and analysis. Among three countries，UK is the main country where science communication theory originated，the United States is a country with highly mature commercialization of science popularization sector，and Japan is an Asian country with strong scientific and technological strength and close to China in culture and geography. Through the analysis and comparison，the research finds that both UK and Japan tend to put science popularization policies into a high-level national framework，while the US encourages heavily universities and companies to take part in science popularization activities and build related infrastructures towards the public. Besides，all three countries actively use new media to attract public regarding science popularization activities. Based on these discussions，this study suggests that China should attach more importance to releasing more national science popularization policies，and stimulate higher education and enterprises joining science popularization in society. Last but not least，new media technology should be widely applied to improve science popularization toward the public.