In order to evaluate the effect of Top Innovative Talents Cultivation Project in Guangzhou regular senior secondary schools，the project team conducted a sample survey around the overall feelings of students’ independent reports，course participation，teacher-student interaction and satisfaction. It is found that the participating students’ scores on the overall feelings of the school were significantly higher than those of the non-participating students，and the participating students showed a higher level of curriculum participation，teacher-student interaction and satisfaction. At the same time，the factors that affected the effect of the project include the richness and flexibility of the courses and resources provided by schools，the satisfaction of the project to the individualized development needs such as students’ interests and innovative ability，and the comprehensive quality of teachers. It is suggested that Guangzhou regular senior secondary schools should expand the scope of training top innovative talents in an orderly manner，create a good atmosphere for training innovative talents，enhance teachers’ competence and enrich curriculum system，so as to further promote the cultivation effect of innovative talents.