It has been 50 years since China and Mexico established formal diplomatic ties. The bilateral economic and trade cooperation has deepened under the complex and changing international circumstances. In recent years，the trade between Guangdong and Mexico shows a trend of stable growth. The structure of import and export trade reflects the complementarity of both sides，and there is a broad space for future economic and trade cooperation. In recent years，the trade between Guangdong and Mexico has been affected by the trade deficit between China and Mexico and Mexican anti-dumping investigation，the trade friction between China and the United States and regional trade protectionism，COVID-19 and other factors. Based on this，the report puts forward countermeasures and suggestions，such as innovating trade modes，strengthening platform construction in the economic and trade field，promoting digital trade cooperation and actively integrating into the “double cycle”，so as to promote the in-depth economic and trade cooperation between Guangdong and Mexico.