The conclusion of international sister cities and the exchange and cooperation between international sister cities are an important way for local foreign affairs，and also the most basic form of exchanges between cities from different countries. Vigorously promoting the work of international sister cities is conducive to boosting exchanges between Chinese and foreign local governments，and promoting the realization of resource sharing，complementary advantages and win-win situation. Since the reform and opening up，Guangzhou has officially started the pace of international sister city exchanges and cooperation，and has formed a series of fixed mechanisms and brand activities to serve the country’s overall diplomatic objectives with rich and vivid practices，build an open network for local development，promote economic and social achievements and realize people-to-people friendship. Chinese cities should take concrete measures from the main aspects of optimizing the layout of international sister city exchanges，formulating precise communication strategies，consolidating brand activities，and mobilizing non-governmental forces to participate，so as to continuously improve the level of international sister city exchanges，and inject impetus and vitality into the urban internationalization.