Cultivating a comprehensive demonstration area that can focus on Guangzhou’s cultural character and urban development achievements，and focusing the world’s attention with the peak effect，is an important step for Guangzhou to build a “world-class tourism destination”. Haizhu District，as the only city center in Guangzhou that integrates Lingnan culture，ecological culture，industrial culture，sea silk culture，red culture and innovation culture，and has two internationally renowned landmarks，Guangzhou Tower and Canton Fair，as well as three cultural tourism routes of land，water and air，has significant advantages in building a world-class tourism destination demonstration area. However，Haizhu District also has shortcomings such as historical sites and cultural landmarks are not highly developed and revitalized，public support in key areas is not complete，the integration of cultural and tourism industries is not enough，and the pattern of new cultural and tourism industry has not yet been formed. In response，this paper puts forward the following suggestions：firstly，upgrade the level of coordination，promote the linkage of cultural and tourism resources within and outside the region；secondly，increase the investment，improve the construction of cultural and tourism infrastructure；thirdly，plan the whole area，focus on the layout of “one core，three axes and six lines” to create a diversified Haizhu shared by hosts and guests；fourthly，systematically，orderly and efficiently promote area construction with precise target classification；fifthly，cultivate and strengthen the cultural tourism market through policy incentives.