Under the background of implementing the innovation and development strategy all over the country，it has become a new trend that overseas returnees start up innovative entrepreneurship. In recent years，the overall quality of returnee talents has been steadily improved，and they have an international vision，cutting-edge scientific achievements，and have great potential to carry out technological research. Innovative entrepreneurship started by overseas returnees not only enhances industrial competitiveness，but also radially influences the development of upstream and downstream industries. Compared with local entrepreneurs，returnees have complex and diverse needs for innovation and entrepreneurship. Factors such as policy environment，financial support，fertilizing carrier，innovation atmosphere and comprehensive services all constitute the entrepreneurial ecology that supports innovative talents. Guangzhou should create an entrepreneurial ecology，provide effective policy support，offer full-life-cycle financial support，improve quality and efficiency of incubation system，optimize the exchange and display platform，build a convenient and efficient service environment，and strive to build a strategic highland for international innovative talents with sufficient competitive advantages and radial and driving ability.