Combating the COVID-19 is a comprehensive governance practice involving major public crises. Science popularization can internalizes the scientific knowledge of epidemic prevention into social psychology，and avoid the public being misled by rumors，misinformation and pseudo science，so as to deepen the understanding of the epidemic prevention policy and enhance the implementation of public health policy. Based on this，the study examines the driving factors of the science topics related to COVID-19，the role and discourse orientation of the communication subjects，the use of new media technology，and the effect of scientific communication in the background of the Pandemic. Finally，based on the practical problems，the article proposes the possible paths to enhance the effectiveness of scientific communication in public health emergencies.