Due to the impact of Coronavirus epidemic in 2020，the market size of the in vitro diagnostic（IVD）industry has achieved a growth of more than 15% in total，which driving the market size of the core raw materials of IVD reagents to exceed ￥10 billion，an increase of more than 30% compared with 2019. It is estimated that the growth of the raw materials of IVD reagents will be more than 20% in 2021. IVD reagents raw material enterprises in various segments of the market share continues to increase，whereas more than 80% of the products are provided by overseas brands，from which the next 3-5 years import substitution is still the main trend. The Ministry of Science and Technology，State Council China and Securities Regulatory Commission has issued relevant policies to provide guidance for the development of key raw materials industry for in vitro diagnosis. Five IVD reagents raw materials companies submitted an IPO application successively，planning to raise a total of ￥5.933 billion. China’s IVD reagent raw materials industry enters high-speed development，but there are also some restrictions. The enterprises need collaborative breakthrough from intra-industry collaboration and cooperation with government，industry，university，research and funds also in overseas market development.