The newly revised Regulations on the Supervision and Administration of Medical Devices（hereinafter referred to as the Regulations）will be implemented on June 1 2021. The Regulations continue to retain the basic institutional provisions governing the operation and supervision of medical devices. In this paper，through the investigation of the problems encountered by some provincial bureaus in Beijing，Shanghai，Hunan，Shaanxi，Gansu，Henan and other provinces in the actual supervision of medical device management links，the ideas to be solved and constructive suggestions for work，some problems that restrict the development of market subjects，can be solved through the implementation of principal responsibilities and the experience of overseas advanced management. Aiming at the weak links found in the practice of supervision，this paper puts forward some measures and suggestions to perfect and strengthen the supervision system and mechanism，so as to further enhance the pertinence and effectiveness of the medical device management and supervision work.