The high-level construction of the innovative development belt around the bay in the east of Zhongshan City is of great significance for Zhongshan City to implement the “East Inheritance” strategy，to unswervingly promote the eastward development of the city’s bay-circle layout，and to strive to achieve the “three orientations” given by the Guangdong Provincial Party Committee. This paper clarifies the connotation and significance of the construction of the innovative development belt in the east of Zhongshan City in the context of the Guangdong-Hong Kong-Macao Greater Bay Area，analyzes the foundation and existing problems of the construction of the innovative development belt in the east of Zhongshan City，and draws on the construction of typical industrial innovation belts at home and abroad. Based on the experience，this paper puts forward the strategic thinking，spatial layout and several suggestions for the construction of the innovative development belt around the east of Zhongshan City under the background of the Guangdong-Hong Kong-Macao Greater Bay Area. It will further provide strong support for Zhongshan City to accelerate the construction of an important bearing area and a base for the transformation of scientific and technological achievements in the Guangdong-Hong Kong-Macao Greater Bay Area International Science and Technology Innovation Center.