Small and medium-sized enterprises in the Greater Bay Area are the main channels for creating wealth and employment opportunities，but the phenomenon of difficult and expensive financing for small and medium-sized enterprises is prominent. The core of the establishment of the medium-sized enterprises’ credit information system in the Greater Bay Area is to fully integrate the medium-sized enterprises’ credit information data on the basis of the integrated credit system，improve the system’s reward and punishment mechanism，explore new means of financing，and improve utilization rate of information resources to provides a path for solving the financing difficulties of small and medium-sized enterprises.