In 2020，with active explorations made by 21 pilot free trade zones，the tax system reform embarked on its journey，and the cross-border service trade access system was implemented in Hainan Free Trade Port for the first time. The integration and promotion of trade and investment liberalization and facilitation system achieved remarkable results，and the construction of high-level business environment brought great economic benefits. Facing the complex and volatile international situations，the core issues on the reform of the pilot free trade zones are to establish an ecosystem for innovations in high-end core technologies，and to promote the innovations in the systems for the flow of natural persons. Facing the challenges brought by the superposition of de-globalization and the new industrial revolution，the free trade pilot zones，as the “test field” for the reform of open system，should explore the construction of science and technology innovation parks to break through the “stuck neck” technologies，and at the same time，further improve the market rules and share the fruits of economic development under the new development model.