As used herein，12 provinces in the Western Region from 2000 to 2018 of prefecture-level city data are used in the research of western region high-quality industrial development factors by constructing DID model. As for further study we mainly focus on whether the implementation of relevant policies will lead to obvious changes in these key factors，which will affect the high-quality development of the three industries as well. It is found that from the perspective of development efficiency，the fixed asset investment under the government-led model in the western region has had a “crowding-out effect” on other resources in the current period，and there are many inefficient investments and repeated construction. From the perspective of the development stage，most cities in the western region are still in the middle stage of industrialization. This realistic condition determines the impact of the implementation of the new urbanization strategy on the high-quality industrial development. From the perspective of development location，the industrial development of “core” and “peripheral” cities in the western region is still significantly dependent on traditional factor input. The reliance on traditional factor inputs remains significant. The “crowding-out effect” of fixed asset investment in major cities covered by the development strategy of the Yangtze River Economic Belt is relatively unconspicuous. From the perspective of development momentum，there are still some obstacles to the docking of industry，university and research in the western region.