Beijing’s high-quality development requires comprehensive innovation with scientific and technological innovation as the core. With the deepening of the process of building an international scientific and technological innovation center，scientific and technological innovation has become a strategic engine leading Beijing’s high-quality development and play a leading role to a certain extent. In the new era，leading Beijing’s high-quality development with scientific and technological innovation requires adhering to scientific and technological self-reliance，strengthening the high-precision industrial system，and promoting the deep integration of scientific and technological innovation and economic development. We should optimize the strategic path and policy measures，mainly including：enhancing the ability of independent innovation and consolidating the foundation；Improve the quality of the industrial system and consolidate the carrier；Create a high-level innovation and entrepreneurship ecology and open up channels；Improve the innovation system and consolidate the organizational mechanism guarantee；Develop digital economy and cultivate new driving forces.