The COVID-19 pandemic has had an unprecedented impact on all of humanity including the African Francophone countries. This article reviews the development of the pandemic in Francophone Africa，divides the overall response measures in the region into three phases：The first is to adopt national emergency risk control，with economic aid policy；In the second phase，these countries begin to gradually relax or remove some of the restrictions in order to revitalize the economy；In the last phase，the African Francophone countries are forced to tighten the policy again due to the rebound of the pandemic and strengthen cooperation with the international community，shifting the focus of pandemic prevention to vaccination.

Their control measures show a repeated state of “tight-loose-tight again”. With the strong rebound of the third wave of the pandemic，African Francophone countries alone cannot effectively deal with it. The international community should step up assistance to relevant countries，especially the assistance in vaccination. Otherwise，the pandemic may spiral out of control in this region.