With the recurring global pandemic and the new round of technological revolution，tourism development will usher in new development opportunities and challenges. Science and technology innovation is the source of economic growth and social progress，and the underlying variable that promotes tourism development. Digitization，integration，intelligence，virtualization，precision and efficiency have become the main engine of tourism development and the new momentum of high-quality development. This is manifested as the improvement of tourism resource integration，extension of tourism experience，the transformation of tourism marketing，quality ascension of tourism service，innovation of tourism commercial activities，and efficiency of tourism governance under the empowerment of science and technology. Faced with the unprecedented changes，technological innovation is the key to develop tourism industry. However，it is necessary to fully grasp the characteristics and rules of the development of tourism empowered by science and technology，cooperate in the complex competitive environment，and realize sustainable development under the guidance of cultural connotation.