Tourism destination resilience is the ability to resist，adjust and adapt to external disturbances. The assessment of tourism destination resilience is the key to enhance resilience and promote sustainable development of tourism destinations. This study mainly examines the resilience of 21 cities in Guangdong Province to the two shocks from 2001 to 2018 and compares the resilience differences between cities. it is found that the tourism industry in Guangdong Province has been hit by the SARS epidemic in 2003 and the financial crisis in 2008. The tourism resilience of each city shows great differences both in terms of the mean value of tourism resilience of different dimensions and the positive times of tourism resilience of different dimensions.