The Yangtze River Economic Belt covers three regional plates and 11 provinces（or municipalities）of China，the population and economic output account half for the country. Thus，it has a prominent economic position and great development potential，and plays an important role in promoting China’s regional coordinated and high-quality development. In 2020，under the unfavorable effect of COVID-19 and trade friction，the GDP and its proportion of the whole country of the Yangtze River Economic Belt continued to grow，and the inter-regional gap was further reduced. The industrial structure became more optimization，and the development of service industry，industry and strategic emerging industries had its own merits. The three major economic development drivers of investment，consumption and export were mixed. Export rise against the trend，with large fluctuations in some regions. Investment still shows a growth trend，but the growth rate further slowed down，and domestic consumption seriously shrinks.