This paper analyzes the economic development of Yangtze River Delta region in 2020 from three aspects：general overview，key industries and growth drivers. Based on the analysis of strategic opportunities and main challenges，the economic operation of Yangtze River Delta region in 2021 is preliminarily prospected. The main conclusions are as follows：The economy of Yangtze River Delta region grows steadily，but the growth rate continues to decline；the GDP nears 24 trillion yuan，and its share in the national economy is basically stable；the quality of the economy has improved considerably，and the gap between regions remains wide；the industrial structure was steadily upgraded and strategic emerging industries developed rapidly. Investment，consumption and export remained stable on the whole，with slightly weakened driving forces to the GDP，but their structure was further improved. Due to the impact of COVID-19，the economy of the Yangtze River Delta region is subject to greater downside risks，but is expected to maintain positive growth.