At the present stage，China is speeding up to build a new development pattern of “with the domestic circulation as the main body and the domestic and international double circulation mutually promoting”. The creation of new cities with urban oriented development is the main channel to realize the “double cycle”. In recent years，Shanghai，Zhejiang and Shenzhen have made good results in their economic，social，cultural，ecological and institutional construction. Through decades of development，Shanghai，Zhejiang and Shenzhen have put forward different advanced development concepts and defined different development tasks，not only taking measures to local conditions，but also the initiative，and have good development potential in the corresponding fields，providing a new concept and path for the directional development of cities in the new era. This paper on Shanghai，Zhejiang，Shenzhen and in recent years in system innovation，scientific and technological innovation，digital reform，manufacturing transformation，summarizes the high quality to create national system innovation pilot area，namely always adhere to the system innovation as the “main line”，further strengthen scientific and technological innovation，actively promote digital reform，deepening the transformation and upgrading of manufacturing industry.